Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTDYFVB)

• DTT Name: Thioredoxin glutathione reductase (TGR)
• Synonyms: Thioredoxin reductase TR2; Thioredoxin reductase 3; Thioredoxin and glutathione reductase; TGR
• Gene Name: TXNRD3
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Sulfur donor oxidoreductase
• UniProt ID: TRXR3_HUMAN
• TTD ID: T89466
• EC Number: EC 1.8.1.9
• Sequence:
  MERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLV
  GLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTV
  PNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGK
  KVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRH
  NWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQ
  FVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDV
  TVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEG
  TETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDIL
  EDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKK
  ENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAM
  KCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
• Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).
• KEGG Pathway:
  Selenocompound metabolism (hsa00450)
  Pathways in cancer (hsa05200)
  Hepatocellular carcinoma (hsa05225)

References

• [1] Molecular profiling and functional insights of rock bream (Oplegnathus fasciatus) thioredoxin reductase 3-like molecule: investigation of its trans... Gene. 2015 Oct 1;570(1):122-31.