Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTEGYK1)

• DTT Name: T-cell surface glycoprotein CD5 (CD5)
• Synonyms: Lymphocyte antigen T1/Leu-1; LEU1
• Gene Name: CD5
• DTT Type: Literature-reported target; [1]
• UniProt ID: CD5_HUMAN
• TTD ID: T85715
• Sequence:
  MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVC
  SQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHS
  RNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGS
  LGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQ
  NSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAAL
  CDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYC
  KKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGP
  TGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPD
  NSSDSDYDLHGAQRL
• Function: May act as a receptor in regulating T-cell proliferation.
• KEGG Pathway: Hematopoietic cell lineage (hsa04640)

References

• [1] CD5 as a Target for Immune-Based Therapies. Crit Rev Immunol. 2015;35(2):85-115.