Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTEI40H)

DTT Name	Steroidogenic acute regulatory protein (STAR)
Synonyms	Steroidogenic acute regulatory protein, mitochondrial; StARD1; START domain-containing protein 1
Gene Name	STAR
DTT Type	Literature-reported target	[1]
UniProt ID	STAR_HUMAN
TTD ID	T33063
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRALGGPTPSTWINQVRRRSSLLG SRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVF RLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVG PRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLT WLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC
Function	Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
KEGG Pathway	Ovarian steroidogenesis (hsa04913 ) Aldosterone synthesis and secretion (hsa04925 ) Cortisol synthesis and secretion (hsa04927 ) Cushing syndrome (hsa04934 ) Cholesterol metabolism (hsa04979 )
Reactome Pathway	Pregnenolone biosynthesis (R-HSA-196108 )

References

1	Heat shock interferes with steroidogenesis by reducing transcription of the steroidogenic acute regulatory protein gene. Mol Endocrinol. 2001 Aug;15(8):1255-63.