Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTEJA2R)

DTT Name	U3 snoRNP protein IMP3 (IMP3)
Synonyms	U3 small nucleolar ribonucleoprotein protein IMP3; MRPS4; C15orf12; BRMS2
Gene Name	IMP3
DTT Type	Literature-reported target	[1]
UniProt ID	IMP3_HUMAN
TTD ID	T64642
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREDYTRYNQLSRAVRELAR RLRDLPERDQFRVRASAALLDKLYALGLVPTRGSLELCDFVTASSFCRRRLPTVLLKLRM AQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDF DLEA
Function	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
KEGG Pathway	Ribosome biogenesis in eukaryotes (hsa03008 )
Reactome Pathway	Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 ) rRNA modification in the nucleus and cytosol (R-HSA-6790901 )

References

1	L523S, an RNA-binding protein as a potential therapeutic target for lung cancer. Br J Cancer. 2003 Mar 24;88(6):887-94.