General Information of Drug Therapeutic Target (DTT) (ID: TTER0UB)

DTT Name Sterol regulatory element binding protein-1 (SREBF1)
Synonyms bHLHd1; Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP1; SREBP-1; SREBP 1; Class D basic helix-loop-helix protein 1
Gene Name SREBF1
DTT Type
Literature-reported target
[1]
UniProt ID
SRBP1_HUMAN
TTD ID
T47236
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTD
PASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGP
GIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGN
TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLL
QPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDA
EKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKS
AVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTE
VEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSR
GMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGW
AQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQ
AAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRV
DASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYV
AAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVL
STPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYL
QLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL
VEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTP
ASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSS
LRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPR
PTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGG
GTTVTSS
Function
Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Transcriptional activator required for lipid homeostasis.
KEGG Pathway
AMPK signaling pathway (hsa04152 )
Insulin signaling pathway (hsa04910 )
Insulin resistance (hsa04931 )
Non-alcoholic fatty liver disease (hsa04932 )
Alcoholic liver disease (hsa04936 )
Reactome Pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) (R-HSA-1655829 )
Cholesterol biosynthesis (R-HSA-191273 )
PPARA activates gene expression (R-HSA-1989781 )
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168 )
Transcriptional regulation of white adipocyte differentiation (R-HSA-381340 )
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (R-HSA-9029558 )
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (R-HSA-9615017 )
RORA activates gene expression (R-HSA-1368082 )

References

1 Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia. 2003 Jun;46(6):733-49.