Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTERU0T)

DTT Name	Urotensin II (UTS2)
Synonyms	Urotensin-II; UTS2; UII; U-II; HU-II
Gene Name	UTS2
DTT Type	Literature-reported target	[1]
UniProt ID	UTS2_HUMAN
TTD ID	T02346
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTPEELERASLLQILPEML GAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHLLARIWKPYKKRETPDCFW KYCV
Function	Highly potent vasoconstrictor.
KEGG Pathway	Neuroactive ligand-receptor interaction (hsa04080 )
Reactome Pathway	G alpha (q) signalling events (R-HSA-416476 ) Peptide ligand-binding receptors (R-HSA-375276 )

References

1	Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular dise... Trends Cardiovasc Med. 2000 Aug;10(6):229-37.