Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTEYF03)

DTT Name	Cytoplasmic DRAK1 (STK17A)
Synonyms	Serine/threonine-protein kinase 17A; STK17A; DAP kinase-related apoptosis-inducing protein kinase 1
Gene Name	STK17A
DTT Type	Literature-reported target	[1]
BioChemical Class	Kinase
UniProt ID	ST17A_HUMAN
TTD ID	T91323
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.7.11.1
Sequence	MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Function	Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

References

1	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-1 tumor suppressor activity by binding to Smad3 to interrupt its complex for... Oncogene. 2015 Sep 24;34(39):5037-45.