Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTF5NVW)

• DTT Name: Alanine glyoxylate aminotransferase (AGXT)
• Synonyms: Serine--pyruvate aminotransferase; SPAT; Alanine--glyoxylate aminotransferase; AGT1; AGT
• Gene Name: AGXT
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Transaminase
• UniProt ID: SPYA_HUMAN
• TTD ID: T06365
• EC Number: EC 2.6.1.51
• Sequence:
  MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
  KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
  ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
  LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
  YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
  RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
  IGLLGCNATRENVDRVTEALRAALQHCPKKKL
• Function: Catalyzes L-alanine and glyoxylate to pyruvate and glycine. Participates in alanine and aspartate metabolism and glycine, serine and threonine metabolism.
• KEGG Pathway:
  Alanine, aspartate and glutamate metabolism (hsa00250)
  Glycine, serine and threonine metabolism (hsa00260)
  Glyoxylate and dicarboxylate metabolism (hsa00630)
  Metabolic pathways (hsa01100)
  Biosynthesis of antibiotics (hsa01130)
  Carbon metabolism (hsa01200)
  Peroxisome (hsa04146)
• Reactome Pathway:
  Peroxisomal protein import (R-HSA-9033241)
  Glyoxylate metabolism and glycine degradation (R-HSA-389661)
• BioCyc Pathway: MetaCyc:HS10525-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMT-030	DMD82LM	Hyperoxaluria	5C51.2	Terminated	[1]

References

• [1] Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med. 2011 Dec 22;365(25):2357-65.