Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFEUYR)

DTT Name Proto-oncogene c-Crk (c-Crk)
Synonyms P38; Adapter molecule crk
Gene Name CRK
DTT Type
Literature-reported target
 [1]
UniProt ID
CRK_HUMAN
TTD ID
T27297
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS
Function
Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. Isoform Crk-II: Regulates cell adhesion, spreading and migration.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
ErbB signaling pathway (hsa04012 )
Rap1 signaling pathway (hsa04015 )
Chemokine signaling pathway (hsa04062 )
Focal adhesion (hsa04510 )
Fc gamma R-mediated phagocytosis (hsa04666 )
Neurotrophin signaling pathway (hsa04722 )
Regulation of actin cytoskeleton (hsa04810 )
Insulin signaling pathway (hsa04910 )
Bacterial invasion of epithelial cells (hsa05100 )
Shigellosis (hsa05131 )
Pathways in cancer (hsa05200 )
MicroRNAs in cancer (hsa05206 )
Renal cell carcinoma (hsa05211 )
Chronic myeloid leukemia (hsa05220 )
Reactome Pathway
Regulation of actin dynamics for phagocytic cup formation (R-HSA-2029482 )
p130Cas linkage to MAPK signaling for integrins (R-HSA-372708 )
VEGFA-VEGFR2 Pathway (R-HSA-4420097 )
Regulation of signaling by CBL (R-HSA-912631 )
ARMS-mediated activation (R-HSA-170984 )

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Myelodysplastic syndrome 2C82 Bone marrow 1.00E-01 0.1 0.33
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References

1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.