Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFKXOM)

DTT Name	Bacterial NADH-dependent enoyl-ACP reductase (Bact fabI)
Synonyms	Enoyl[acylcarrierprotein] reductase [NADH] FabI; ENR of Mycobacterium tuberculosis
Gene Name	Bact fabI
DTT Type	Literature-reported target	[1]
BioChemical Class	Short-chain dehydrogenases reductase
UniProt ID	FABI_ECOLI
TTD ID	T53588
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIV LQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDIS SYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPE GVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGI SGEVVHVDGGFSIAAMNELELK
Function	Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.
KEGG Pathway	Fatty acid biosynthesis (ecj00061 ) Biotin metabolism (ecj00780 ) Metabolic pathways (ecj01100 ) Biosynthesis of secondary metabolites (ecj01110 ) Fatty acid metabolism (ecj01212 ) Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway	MetaCyc:ENOYL-ACP-REDUCT-NADH-MON EcoCyc:ENOYL-ACP-REDUCT-NADH-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MUT-056399	DMC3NSK	Methicillin-resistant staphylococci infection	1A00-1A09	Preclinical	[1]
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References

1	The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.