General Information of Drug Therapeutic Target (DTT) (ID: TTFLIKM)

DTT Name Apoptosis-related protein 3 (ATRAID)
Synonyms p18; C2orf28
Gene Name ATRAID
DTT Type
Literature-reported target
[1]
UniProt ID
ARAID_HUMAN
TTD ID
T96398
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPHDPGSLTTLVPWAAALLLALGVERALALPEICTQCPGSVQNLSKVAFYCKTTRELML
HARCCLNQKGTILGLDLQNCSLEDPGPNFHQAHTTVIIDLQANPLKGDLANTFRGFTQLQ
TLILPQHVNCPGGINAWNTITSYIDNQICQGQKNLCNNTGDPEMCPENGSCVPDGPGLLQ
CVCADGFHGYKCMRQGSFSLLMFFGILGATTLSVSILLWATQRRKAKTS
Function Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.

References

1 Apoptosis related protein 3 is a lysosomal membrane protein. Biochem Biophys Res Commun. 2015 May 15;460(4):915-22.