Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTFS1T2)
| DTT Name | Serpin I2 (SERPINI2) | ||||
|---|---|---|---|---|---|
| Synonyms | Peptidase inhibitor 14; Pancreas-specific protein TSA2004; Pancpin; PI14; PI-14; Myoepithelium-derived serine protease inhibitor; MEPI | ||||
| Gene Name | SERPINI2 | ||||
| DTT Type |
Literature-reported target
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[1] | |||
| BioChemical Class |
Serpin protein
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| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| Sequence |
MDTIFLWSLLLLFFGSQASRCSAQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQ
LGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVK EQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLV NAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELS YKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKD VLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSL AQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL |
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| Function |
A member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors.Plays central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation.
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