Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFSUIA)

DTT Name	Vesicular H(+)/Aspartate-glutamate cotransporter (HP59)
Synonyms	Solute carrier family 17 member 5; Sodium/sialic acid cotransporter; SLC17A5; Membrane glycoprotein HP59; AST
Gene Name	SLC17A5
DTT Type	Literature-reported target	[1]
BioChemical Class	Major facilitator superfamily
UniProt ID	S17A5_HUMAN
TTD ID	T44305
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNL SVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYI ITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFP AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFW FLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFS YNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFST LCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPS YAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKG EVQNWALNDHHGHRH
Function	Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
KEGG Pathway	Lysosome (hsa04142 )
Reactome Pathway	Organic anion transporters (R-HSA-428643 ) Defective SLC17A5 causes Salla disease (SD) and ISSD (R-HSA-5619035 ) Sialic acid metabolism (R-HSA-4085001 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5) DTP Info

Gene Name

SLC17A5

2 Investigative Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NAAG	DMFGOW0	Discovery agent	N.A.	Investigative	[2]
NITRATE	DMVFB93	Discovery agent	N.A.	Investigative	[3]
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References

1	Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis. Clin Cancer Res. 2001 Dec;7(12):4182-94.
2	Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8.
3	Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9.