Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFX379)

DTT Name	Rhombotin-2 (LMO2)
Synonyms	TTG2; T-cell translocation protein 2; RHOM2; RBTNL1; RBTN2; LMO-2; LIM-only protein 2; LIM-domain protein Lmo2; LIM domain only protein 2; Cysteine-rich protein TTG-2; Cysteine rich protein TTG-2
Gene Name	LMO2
DTT Type	Literature-reported target	[1]
UniProt ID	RBTN2_HUMAN
TTD ID	T88321
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLC GCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECF KCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI
Function	Acts with LDB1 to maintain erythroid precursors in an immature state. Acts with TAL1/SCL to regulate red blood cell development.
KEGG Pathway	Transcriptional misregulation in cancer (hsa05202 )
Reactome Pathway	RUNX1 regulates transcription of genes involved in differentiation of HSCs (R-HSA-8939236 )

References

1	The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target. Oncogene. 2002 Feb 21;21(9):1309-15.