Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTG2XRE)

• DTT Name: Solute carrier family 15 member 4 (SLC15A4)
• Synonyms: SLC15A4
• Gene Name: SLC15A4
• DTT Type: Literature-reported target; [1]
• UniProt ID: S15A4_HUMAN
• TTD ID: T09063
• Sequence:
  MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVL
  FLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAF
  PLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGA
  DQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVF
  LCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCK
  MSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTT
  PHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAG
  ILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAA
  PKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLA
  AIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA
• Function: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.
• Reactome Pathway:
  Neutrophil degranulation (R-HSA-6798695)
  Proton/oligopeptide cotransporters (R-HSA-427975)

Molecular Interaction Atlas (MIA) of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]histidine	DMVUF71	Discovery agent	N.A.	Investigative	[2]
[3H]histidine	DMJ5BDQ	N. A.	N. A.	Investigative	[1]

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Peptide transporter 4 (SLC15A4) DTP Info
• Gene Name: SLC15A4

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 987).
• [2] Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem. 1997 Apr 11;272(15):10205-11.