Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTG8ZWP)

DTT Name ADRB2 messenger RNA (ADRB2 mRNA)
Synonyms Beta-2 adrenoreceptor (mRNA); Beta-2 adrenoceptor (mRNA); Beta-2 adrenergic receptor (mRNA); B2AR (mRNA); ADRB2R (mRNA)
Gene Name ADRB2
DTT Type
Clinical trial target
 [1]
BioChemical Class
mRNA target
UniProt ID
ADRB2_HUMAN
TTD ID
T24555
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Function
The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.
KEGG Pathway
Calcium signaling pathway (hsa04020 )
cGMP-PKG signaling pathway (hsa04022 )
cAMP signaling pathway (hsa04024 )
Neuroactive ligand-receptor interaction (hsa04080 )
Endocytosis (hsa04144 )
Adrenergic signaling in cardiomyocytes (hsa04261 )
Salivary secretion (hsa04970 )
Reactome Pathway
G alpha (s) signalling events (R-HSA-418555 )
Adrenoceptors (R-HSA-390696 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bamosiran DM0TZEP Glaucoma/ocular hypertension 9C61 Phase 2 [2]
SYL-040012 DMXLE71 Ocular hypertension 9C61.01 Phase 2 [1]
------------------------------------------------------------------------------------

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Asthma CA23 Nasal and bronchial airway 3.52E-02 0.25 0.34
Chronic obstructive pulmonary disease CA23 Lung tissue 4.88E-01 -0.05 -0.12
Chronic obstructive pulmonary disease CA23 Small airway epithelium 7.10E-01 0.06 0.09
Preterm birth KA21.4Z Myometrium 1.10E-01 0.55 0.97
------------------------------------------------------------------------------------

References

1 In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma. Mol Ther. 2014 Jan;22(1):81-91.
2 Clinical pipeline report, company report or official report of Sylentis.