Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGN89I)

DTT Name Interleukin 15 receptor alpha (IL15RA)
Synonyms
sIL15Ralpha; sIL15RA; sIL15 receptor subunit alpha; Soluble interleukin15 receptor subunit alpha; Interleukin-15 receptor subunit alpha; IL15Ralpha; IL15 receptor subunit alpha; IL-15RA; IL-15R-alpha; IL-15 receptor subunit alpha; CD215
Gene Name IL15RA
DTT Type
Clinical trial target
 [1]
BioChemical Class
Cytokine receptor
UniProt ID
I15RA_HUMAN
TTD ID
T48429
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICN
SGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPE
SLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTA
KNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVE
MEAMEALPVTWGTSSRDEDLENCSHHL
Function
Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. High-affinity receptor for interleukin-15.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
Jak-STAT signaling pathway (hsa04630 )
Intestinal immune network for IgA production (hsa04672 )
HTLV-I infection (hsa05166 )
Reactome Pathway
Interleukin-15 signaling (R-HSA-8983432 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALT-803 DMK3U1X Acute myeloid leukaemia 2A60 Phase 2 [2]
NKTR-255 DM7SMNJ Colorectal cancer 2B91.Z Phase 1/2 [3]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor alphaSu/Fc fusion complex in syngeneic murine models of multiple myeloma. Cancer Res. 2013 May 15;73(10):3075-86.
3 Clinical pipeline report, company report or official report of Nektar Therapeutics.