Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGQ6MI)

• DTT Name: Mucin-15 (MUC15)
• Synonyms: Mucin15; MUC15
• Gene Name: MUC15
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Mucin
• UniProt ID: MUC15_HUMAN
• TTD ID: T58216
• Sequence:
  MLALAKILLISTLFYSLLSGSHGKENQDINTTQNIAEVFKTMENKPISLESEANLNSDKE
  NITTSNLKASHSPPLNLPNNSHGITDFSSNSSAEHSLGSLKPTSTISTSPPLIHSFVSKV
  PWNAPIADEDLLPISAHPNATPALSSENFTWSLVNDTVKTPDNSSITVSILSSEPTSPSV
  TPLIVEPSGWLTTNSDSFTGFTPYQEKTTLQPTLKFTNNSKLFPNTSDPQKENRNTGIVF
  GAILGAILGVSLLTLVGYLLCGKRKTDSFSHRRLYDDRNEPVLRLDNAPEPYDVSFGNSS
  YYNPTLNDSAMPESEENARDGIPMDDIPPLRTSV
• Function: May play a role in the cell adhesion to the extracellular matrix.
• Reactome Pathway:
  Defective C1GALT1C1 causes TNPS (R-HSA-5083632)
  Defective GALNT12 causes CRCS1 (R-HSA-5083636)
  Dectin-2 family (R-HSA-5621480)
  O-linked glycosylation of mucins (R-HSA-913709)
  Termination of O-glycan biosynthesis (R-HSA-977068)
  Defective GALNT3 causes HFTC (R-HSA-5083625)

References

• [1] Expression of mucin 15 in hepatocellular carcinoma and its clinical implications. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1611-5.