Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGQUFK)

• DTT Name: PI3K/AKT/mTOR pathway (PAm pathway)
• Gene Name: PAm pathway
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T90695

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[1]
Glypromate	DM0OX31	Neurological disorder	6B60	Phase 4	[2]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ON-01210.Na	DMWYEDX	Acute radiation syndrome	NF00	Phase 1	[3]

References

• [1] The genomic landscape of nasopharyngeal carcinoma.Nat Genet. 2014 Aug;46(8):866-71.
• [2] Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat. 2014; 8: 97.
• [3] ON01210.Na (Ex-RAD ) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355.