Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGT87E)

DTT Name	DNA repair protein complementing XP-A cells (XPA)
Synonyms	Xeroderma pigmentosum group A-complementing protein; XPAC; XPA protein
Gene Name	XPA
DTT Type	Literature-reported target	[1]
UniProt ID	XPA_HUMAN
TTD ID	T48040
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
Function	Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Involved in DNA excision repair.
KEGG Pathway	Platinum drug resistance (hsa01524 ) Nucleotide excision repair (hsa03420 )
Reactome Pathway	Dual Incision in GG-NER (R-HSA-5696400 ) Formation of TC-NER Pre-Incision Complex (R-HSA-6781823 ) Dual incision in TC-NER (R-HSA-6782135 ) Formation of Incision Complex in GG-NER (R-HSA-5696395 )

References

1	A truncated human xeroderma pigmentosum complementation group A protein expressed from an adenovirus sensitizes human tumor cells to ultraviolet li... Cancer Res. 2001 Jan 15;61(2):764-70.