Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGT9C7)

DTT Name Bcl-2-related protein A1 (BCL2A1)
Synonyms Protein GRS; Protein BFL-1; Hemopoietic-specific early response protein; HBPA1; GRS; Bcl2-L-5; Bcl-2-like protein 5; BFL1; BCL2L5
Gene Name BCL2A1
DTT Type
Patented-recorded target
 [1]
UniProt ID
B2LA1_HUMAN
TTD ID
T12797
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
Function
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).
KEGG Pathway
NF-kappa B signaling pathway (hsa04064 )
Apoptosis (hsa04210 )
Transcriptional misregulation in cancer (hsa05202 )
Acute myeloid leukemia (hsa05221 )
Reactome Pathway
Nuclear events stimulated by ALK signaling in cancer (R-HSA-9725371 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apogossypolone DM7AXSM N. A. N. A. Patented [2]
US8937193-compound-6b DM6EMYB N. A. N. A. Patented [2]
US8937193-compound-7 DMHZJEA N. A. N. A. Patented [2]
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References

1 Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. J Exp Med. 2001 Dec 3;194(11):1561-69.
2 Apogossypolone derivatives as anticancer agents. US8937193.