Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGTKX9)

DTT Name	Regulator of G-protein signaling 4 (RGS4)
Synonyms	RGP4
Gene Name	RGS4
DTT Type	Literature-reported target	[1]
UniProt ID	RGS4_HUMAN
TTD ID	T93580
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWA ESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFIS VQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNP SSCGAEKQKGAKSSADCASLVPQCA
Function	Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Reactome Pathway	G alpha (i) signalling events (R-HSA-418594 ) G alpha (z) signalling events (R-HSA-418597 ) G alpha (q) signalling events (R-HSA-416476 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCG-50014	DMUQJ6X	Discovery agent	N.A.	Investigative	[1]
RGS4 inhibitor 13	DM4XVLB	Discovery agent	N.A.	Investigative	[1]
thiadiazolidinone (TDZD) deriv. 6	DM9CF45	Discovery agent	N.A.	Investigative	[1]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2811).