Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGTWLF)

DTT Name	Vasoactive intestinal polypeptide (VIP)
Synonyms	Vasoactive intestinal peptide; VIP peptides; Peptide histidine valine 42; Intestinal peptide PHV-42
Gene Name	VIP
DTT Type	Literature-reported target	[1]
UniProt ID	VIP_HUMAN
TTD ID	T88213
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
Function	VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
KEGG Pathway	cAMP signaling pathway (hsa04024 ) Neuroactive ligand-receptor interaction (hsa04080 )
Reactome Pathway	Glucagon-type ligand receptors (R-HSA-420092 ) ADORA2B mediated anti-inflammatory cytokines production (R-HSA-9660821 ) G alpha (s) signalling events (R-HSA-418555 )

References

1	The effect of vasoactive intestinal polypeptide on gastric acid secretion is predominantly mediated by somatostatin. Gastroenterology. 1991 May;100(5 Pt 1):1195-200.