Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGUJAO)

DTT Name	Immunoglobulin alpha Fc receptor (FCAR)
Synonyms	IgA Fc receptor; FCAR; CD89 antigen; CD89
Gene Name	FCAR
DTT Type	Discontinued target	[1]
UniProt ID	FCAR_HUMAN
TTD ID	T45737
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDPKQTTLLCLVLCLGQRIQAQEGDFPMPFISAKSSPVIPLDGSVKIQCQAIREAYLTQL MIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQCQYRIGHYRFRYSDTLELVVT GLYGKPFLSADRGLVLMPGENISLTCSSAHIPFDRFSLAKEGELSLPQHQSGEHPANFSL GPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNLIRMAVAGLVLVA LLAILVENWHSHTALNKEASADVAEPSWSQQMCQPGLTFARTPSVCK
Function	Binds to the fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
KEGG Pathway	Phagosome (hsa04145 ) Staphylococcus aureus infection (hsa05150 )
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MDX-214	DMXB20Y	Autoimmune diabetes	5A10	Discontinued in Phase 1/2	[1]
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References

1	A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of MDX-214, a novel immune-mediated mechanism agent targeting the epithelial growth factor receptor (EGFR), in patients with advanced solid tumors. Journal of Clinical Oncology, Vol 24, No 18S (June 20 Supplement), 2006: 2523.