Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTGX13H)

DTT Name Fatty-acid amide hydrolase 1 (FAAH1)
Synonyms Oleamide hydrolase 1 of mouse; Oleamide hydrolase 1; FAAH; Anandamide amidohydrolase 1 of mouse; Anandamide amidohydrolase 1
Gene Name FAAH1
DTT Type
Patented-recorded target
 [1]
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
FAAH1_HUMAN
TTD ID
T34389
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.5.1.99
Sequence
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
Function
Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
KEGG Pathway
Retrograde endocannabinoid signaling (hsa04723 )
Reactome Pathway
Arachidonic acid metabolism (R-MMU-2142753 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
10 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamate derivative 2 DMEWPQ6 N. A. N. A. Patented [1]
Carbamate derivative 4 DM9MFDH N. A. N. A. Patented [1]
Carbamate derivative 5 DMHB5XG N. A. N. A. Patented [1]
Carbamate derivative 6 DMMOSKZ N. A. N. A. Patented [1]
Carbamide derivative 1 DMXQTPJ N. A. N. A. Patented [1]
Carbamoyl oxime derivative 1 DM0EBS8 N. A. N. A. Patented [1]
Ethylaminopyrimidine derivative 1 DMTBG39 N. A. N. A. Patented [1]
Piperazine urea derivative 2 DM5OCM7 N. A. N. A. Patented [1]
PMID26413912-Compound-84 DMNOJGW N. A. N. A. Patented [1]
Pyrimidinyl ethylenediamine derivative 1 DMZ83P1 N. A. N. A. Patented [1]
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⏷ Show the Full List of 10 Patented Agent(s)

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Oleamide hydrolase 1 (FAAH) DME Info
Gene Name FAAH
1 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [2]
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References

1 Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66.
2 Update of TTD: therapeutic target database. Nucleic Acids Res. 2010 Jan;38(Database issue):D787-91.