Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTH29K0)

DTT Name	Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC)
Synonyms	nadC; Quinolinic acid phosphoribosyltransferase; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase
Gene Name	MycB nadC
DTT Type	Literature-reported target	[1]
BioChemical Class	Pentosyltransferase
UniProt ID	NADC_MYCTU
TTD ID	T44515
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.4.2.19
Sequence	MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVAL LTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATA TAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAG SVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRA PTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM
Function	Involved in the catabolism of quinolinic acid (QA).
KEGG Pathway	Nicotinate and nicotinamide metabolism (mtu00760 ) Metabolic pathways (mtu01100 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

4 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5-Phosphoribosyl-1-(Beta-Methylene) Pyrophosphate	DMGK05W	Discovery agent	N.A.	Investigative	[1]
Namn	DM1EZ3N	Discovery agent	N.A.	Investigative	[1]
Phthalic Acid	DMF9T64	Discovery agent	N.A.	Investigative	[1]
Quinolinic Acid	DM8YGOI	Discovery agent	N.A.	Investigative	[1]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.