Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTH9LDP)

DTT Name	PC4 and SFRS1-interacting protein (PSIP1)
Synonyms	Transcriptional coactivator p75/p52; PSIP2; Lens epithelium-derived growth factor; LEDGF; Dense fine speckles 70 kDa protein; DFS70; DFS 70; CLL-associated antigen KW-7
Gene Name	PSIP1
DTT Type	Patented-recorded target	[1]
UniProt ID	PSIP1_HUMAN
TTD ID	T83196
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
Function	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
KEGG Pathway	Viral life cycle - HIV-1 (hsa03250 )
Reactome Pathway	2-LTR circle formation (R-HSA-164843 ) Integration of viral DNA into host genomic DNA (R-HSA-175567 ) Autointegration results in viral DNA circles (R-HSA-177539 ) APOBEC3G mediated resistance to HIV-1 infection (R-HSA-180689 ) Vpr-mediated nuclear import of PICs (R-HSA-180910 ) Integration of provirus (R-HSA-162592 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

3 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9132129, Cpd002	DM9RIF4	N. A.	N. A.	Patented	[2]
US9132129, Cpd023	DMG18XH	N. A.	N. A.	Patented	[2]
US9132129, Cpd047	DM17YHP	N. A.	N. A.	Patented	[2]
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References

1	LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. Blood. 2018 Jan 4;131(1):95-107.
2	Antiviral compounds. US9132129.