Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHCEF6)

• DTT Name: VCAM-1 messenger RNA (VCAM1 mRNA)
• Synonyms: Vascular cell adhesion protein 1 (mRNA); Vascular cell adhesion molecule 1 (mRNA); VCAM-1 (mRNA); V-CAM 1 (mRNA); INCAM-100 (mRNA); CD106 antigen (mRNA); CD106 (mRNA)
• Gene Name: VCAM1
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: VCAM1_HUMAN
• TTD ID: T68026
• Sequence:
  MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
  TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
  IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
  TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
  SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
  RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
  SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
  VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
  LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
  APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
  KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
  KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
  RKANMKGSYSLVEAQKSKV
• Function: Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. Important in cell-cell recognition.
• KEGG Pathway:
  NF-kappa B signaling pathway (hsa04064)
  Cell adhesion molecules (CAMs) (hsa04514)
  TNF signaling pathway (hsa04668)
  Leukocyte transendothelial migration (hsa04670)
  African trypanosomiasis (hsa05143)
  Malaria (hsa05144)
  HTLV-I infection (hsa05166)
• Reactome Pathway:
  Integrin cell surface interactions (R-HSA-216083)
  Interferon gamma signaling (R-HSA-877300)
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (R-HSA-198933)

Molecular Interaction Atlas (MIA) of This DTT

9 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 3792	DMBE1T8	Discovery agent	N.A.	Investigative	[1]
ISIS 3801	DMJDWX5	Discovery agent	N.A.	Investigative	[1]
ISIS 3804	DM7VAT0	Discovery agent	N.A.	Investigative	[1]
ISIS 3805	DMX927V	Discovery agent	N.A.	Investigative	[1]
ISIS 5874	DMYVST6	Discovery agent	N.A.	Investigative	[1]
ISIS 5875	DM8T1Z4	Discovery agent	N.A.	Investigative	[1]
ISIS 5876	DMRATOH	Discovery agent	N.A.	Investigative	[1]
ISIS 5884	DME7698	Discovery agent	N.A.	Investigative	[1]
SYMBIOPOLYOL	DM28TXP	Discovery agent	N.A.	Investigative	[2]

References

• [1] US patent application no. 5,843,738, Oligonucleotide modulation of cell adhesion.
• [2] Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua. J Nat Prod. 2010 Jul 23;73(7):1318-22.