Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHDSE2)

• DTT Name: Bacterial Fumarate reductase flavoprotein (Bact frdA)
• Synonyms: Fumarate reductase; FRDA
• Gene Name: Bact frdA
• DTT Type: Successful target; [1]
• Related Disease:
  Hydrocephalus [ICD-11: 8D64]
  Nematode disease [ICD-11: 1F6Y]
  Parasitic worm infestation [ICD-11: 1F90]
  Trichuriasis [ICD-11: 1F6G]
• BioChemical Class: CH-CH donor oxidoreductase
• UniProt ID: FRDA_HELPY
• TTD ID: T31230
• EC Number: EC 1.3.5.4
• Sequence:
  MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKK
  SEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVN
  GEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKD
  MLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
  LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELAS
  RDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADS
  KEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGE
  AACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
  LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHN
  NPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQ
  DMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEV
  QHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE
• Function: Two distinct, membrane-bound, fad-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; The fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.
• KEGG Pathway:
  Citrate cycle (TCA cycle) (hpy00020)
  Oxidative phosphorylation (hpy00190)
  Pyruvate metabolism (hpy00620)
  Butanoate metabolism (hpy00650)
• BioCyc Pathway: MetaCyc:HP0192-MON

Molecular Interaction Atlas (MIA) of This DTT

3 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Morantel tartrate	DM560Y3	Mature gastrointestinal nematode infection	1F6Y	Approved	[1], [2]
Oxantel pamoate	DMZ30JT	Trichuris trichiura infection	1F6G	Approved	[1]
Thiabendazole	DM7YCK3	Dutch elm disease	8D64	Approved	[1]

8 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,3-DIMETHYL-1,4-NAPHTHOQUINONE	DMGXVBA	Discovery agent	N.A.	Investigative	[3]
2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE	DMJ3ATL	Discovery agent	N.A.	Investigative	[3]
2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL	DMUZDSC	Discovery agent	N.A.	Investigative	[3]
Citraconic acid	DMCIM9A	Discovery agent	N.A.	Investigative	[4]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[5]
Fumarate	DM9VLS2	Discovery agent	N.A.	Investigative	[5]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[3]
Malate Like Intermediate	DM4OQWZ	Discovery agent	N.A.	Investigative	[4]

References

• [1] Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87.
• [2] Fumarate reductase: a target for therapeutic intervention against Helicobacter pylori. Arch Biochem Biophys. 1995 Aug 1;321(1):153-9.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [4] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.