Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHKJLN)

DTT Name DNA-directed RNA polymerase (RNAP)
Gene Name RNAP
DTT Type
Successful target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T17003

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifabutin DM1YBHK Mycobacterium infection 1B10-1B21 Approved [2]
Rifapentine DMCHV4I Pulmonary tuberculosis 1B10.Z Approved [1]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifaximin DR DMKTS2M Crohn disease DD70 Phase 3 [3]
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References

1 Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)