Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHONFT)

• DTT Name: MHC class I antigen A*33 (HLA-A)
• Synonyms: HLAA; HLA-A; HLA class I histocompatibility antigen, A33 alpha chain; Aw33; Aw19
• Gene Name: HLA-A
• DTT Type: Literature-reported target; [1]
• BioChemical Class: MHC class I
• UniProt ID: 1A33_HUMAN
• TTD ID: T08985
• Sequence:
  MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF
  DSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQ
  IMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQL
  RAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT
  WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL
  SSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSL
  TACKV
• Function: Involved in the presentation of foreign antigens to the immune system.

References

• [1] HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008 Dec;122(6):1271-6.