Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHVCUP)

DTT Name	DNA [cytosine-5]-methyltransferase (DNMT)
Synonyms	DNA MTase
Gene Name	NO-GeName
DTT Type	Successful target	[1]
Related Disease	Myelodysplastic syndrome [ICD-11: 2A37]
UniProt ID	NOUNIPROTAC
TTD ID	T92308
Function	This methylase recognizes the double-stranded sequence ccwgg, causes specific methylation on c-2 on both strands.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Myelodysplastic syndrome	2A37	Approved	[1]
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3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASTX727	DM4HK8Z	Chronic myelogenous leukaemia	2A20.0	Phase 3	[2]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
S-110	DMXY34J	Acute myeloid leukaemia	2A60	Phase 3	[4]
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4 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27376512-Compound-CROs	DMBFUTL	N. A.	N. A.	Patented	[5]
PMID27376512-Compound-MTC-434	DM70CTE	N. A.	N. A.	Patented	[5]
PMID27376512-Compound-PG-11047	DM5K4YF	N. A.	N. A.	Patented	[5]
PMID27376512-Compound-PG-11048	DM3U7RN	N. A.	N. A.	Patented	[5]
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17 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[6], [3]
NSC-106084	DM6ID8P	Discovery agent	N.A.	Investigative	[3]
NSC-137546	DMKQYMX	Discovery agent	N.A.	Investigative	[3]
NSC-138419	DMH684Q	Discovery agent	N.A.	Investigative	[3]
NSC-154957	DMW82SA	Discovery agent	N.A.	Investigative	[3]
NSC-158324	DMDR460	Discovery agent	N.A.	Investigative	[3]
NSC-319745	DMF3G06	Discovery agent	N.A.	Investigative	[3]
NSC-345763	DM2UPSV	Discovery agent	N.A.	Investigative	[3]
NSC-348926	DM3TDEO	Discovery agent	N.A.	Investigative	[3]
NSC-401077	DM0214E	Discovery agent	N.A.	Investigative	[3]
NSC-54162	DMW2Q6N	Discovery agent	N.A.	Investigative	[3]
NSC-56071	DMLEN4X	Discovery agent	N.A.	Investigative	[3]
NSC-57893	DMIRK41	Discovery agent	N.A.	Investigative	[3]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[3]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[3]
NSC-623548	DMW437Z	Discovery agent	N.A.	Investigative	[3]
S-tubercidinylhomocysteine	DM9UHCY	Discovery agent	N.A.	Investigative	[7]
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⏷ Show the Full List of 17 Investigative Drug(s)

References

1	The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid l... Leukemia. 2009 Jun;23(6):1019-28.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30.
6	Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6.
7	SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51.