Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHWB7G)

• DTT Name: Bacterial Penicillin binding protein 2 (Bact mrdA)
• Synonyms: PBP-2
• Gene Name: Bact mrdA
• DTT Type: Successful target; [1]
• UniProt ID: MRDA_ECOLI
• TTD ID: T66040
• EC Number: EC 3.4.16.4
• Sequence:
  MKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIK
  LVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALRSVVDLTDDDIAAFR
  KERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYKRRYYPYGSALTHVIGYVS
  KINDKDVERLNNDGKLANYAATHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLK
  EVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGVLALVSTPSYDPNLFVDG
  ISSKDYSALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTTLFDPGWWQL
  PGSEKRYRDWKKWGHGRLNVTRSLEESADTFFYQVAYDMGIDRLSEWMGKFGYGHYTGID
  LAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGIVKV
  PHLLMSTAEDGKQVPWVQPHEPPVGDIHSGYWELAKDGMYGVANRPNGTAHKYFASAPYK
  IAAKSGTAQVFGLKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAV
  GTLMRQILDHIMLGDNNTDLPAENPAVAAAEDH
• Function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. It synthesizes cross- linked peptidoglycan from lipid intermediates.
• KEGG Pathway:
  Peptidoglycan biosynthesis (ecj00550)
  Metabolic pathways (ecj01100)
  beta-Lactam resistance (ecj01501)
• BioCyc Pathway:
  MetaCyc:EG10606-MON
  EcoCyc:EG10606-MON

Molecular Interaction Atlas (MIA) of This DTT

3 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amdinocillin	DMIG6FY	Bacterial infection	1A00-1C4Z	Approved	[2]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[3]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[1]

References

• [1] A comparative trial of imipenem versus ceftazidime in the release of endotoxin and cytokine generation in patients with gram-negative urosepsis. Urosepsis Study Group. J Endotoxin Res. 2000;6(1):25-31.
• [2] Growth of Escherichia coli: significance of peptidoglycan degradation during elongation and septation. J Bacteriol. 2008 Jun;190(11):3914-22.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.