Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTI6V13)

DTT Name	Cardiotrophin-like cytokine factor 1 (CLCF1)
Synonyms	Novel neurotrophin1; NNT1; CLCF1; Bcellstimulating factor 3; BSF3
Gene Name	CLCF1
DTT Type	Literature-reported target	[1]
UniProt ID	CLCF1_HUMAN
TTD ID	T84019
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGT YLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGL NRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQ KMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF
Function	Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
Reactome Pathway	IL-6-type cytokine receptor ligand interactions (R-HSA-6788467 )

References

1	Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative di... Cytokine Growth Factor Rev. 2015 Oct;26(5):517-22.