Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIF3GB)

• DTT Name: Glucose transporter type 9 (GLUT9)
• Synonyms: Urate transporter; Solute carrier family 2, facilitated glucose transporter member 9; GLUT9; GLUT-9
• Gene Name: SLC2A9
• DTT Type: Discontinued target; [1]
• UniProt ID: GTR9_HUMAN
• TTD ID: T00523
• Sequence:
  MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVAS
  LAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIG
  GLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGV
  ALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
  PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIR
  LVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLST
  GGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGIL
  AIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
  FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP
• Function: Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose.
• Reactome Pathway:
  Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) (R-HSA-5619047)
  Cellular hexose transport (R-HSA-189200)

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAP-001	DM4DP70	Gout	FA25	Phase 2	[2]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AA-193	DMB5TH3	Hyperuricaemia	5C55.Y	Discontinued in Phase 2	[1]

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Glucose transporter type 9 (SLC2A9) DTP Info
• Gene Name: SLC2A9

References

• [1] Uricosurics inhibit urate transporter in rat renal brush border membrane vesicles. Eur J Pharmacol. 1990 Oct 23;187(3):303-12.
• [2] Clinical pipeline report, company report or official report of Shanton Pharma Shanghai, China