Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIM2WO)

DTT Name	Neurotrophin-4 (NTF4)
Synonyms	Neutrophic factor 4; Neurotrophin5; Neurotrophin4; Neurotrophin-5; NTF5; NT4; NT-5; NT-4
Gene Name	NTF4
DTT Type	Literature-reported target	[1]
BioChemical Class	Growth factor
UniProt ID	NTF4_HUMAN
TTD ID	T00902
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL TADAQGRVGWRWIRIDTACVCTLLSRTGRA
Function	Target-derived survival factor for peripheral sensory sympathetic neurons.
KEGG Pathway	MAPK signaling pathway (hsa04010 ) Neurotrophin signaling pathway (hsa04722 )
Reactome Pathway	Activated NTRK2 signals through RAS (R-HSA-9026519 ) Activated NTRK2 signals through PLCG1 (R-HSA-9026527 ) Activated NTRK2 signals through PI3K (R-HSA-9028335 ) Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731 ) NTF4 activates NTRK2 (TRKB) signaling (R-HSA-9026357 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ReN-1826	DMGY51F	Central nervous system disease	8A04-8D87	Terminated	[1]
------------------------------------------------------------------------------------

References

1	Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J Allergy Clin Immunol. 2006 Sep;118(3):597-605.