Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTINE9B)

DTT Name Lymphocyte antigen 6D (LY6D)
Synonyms LY6D; E48 antigen; Desmoglein III (dg4)
Gene Name LY6D
DTT Type
Literature-reported target
 [1]
UniProt ID
LY6D_HUMAN
TTD ID
T03317
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRTALLLLAALAVATGPALTLRCHVCTSSSNCKHSVVCPASSRFCKTTNTVEPLRGNLVK
KDCAESCTPSYTLQGQVSSGTSSTQCCQEDLCNEKLHNAAPTRTALAHSALSLGLALSLL
AVILAPSL
Function May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.
Reactome Pathway
Post-translational modification (R-HSA-163125 )

References

1 The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell a... J Cell Biol. 1995 Jun;129(6):1677-89.