Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIS4OW)

DTT Name	Phosphodiesterase 8 (PDE8)
Synonyms	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Gene Name	PDE8A
DTT Type	Patented-recorded target	[1]
BioChemical Class	Phosphoric diester hydrolase
UniProt ID	PDE8A_HUMAN
TTD ID	T05904
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.1.4.53
Sequence	MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
Function	May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
KEGG Pathway	Purine metabolism (hsa00230 ) Metabolic pathways (hsa01100 ) Cortisol synthesis and secretion (hsa04927 ) Cushing syndrome (hsa04934 ) Morphine addiction (hsa05032 )
Reactome Pathway	G alpha (s) signalling events (R-HSA-418555 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

6 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AC1M1SP5	DMEW5LD	N. A.	N. A.	Patented	[2]
BC11-28	DMTWIE2	N. A.	N. A.	Patented	[2]
US8846654, 11	DMRUTJZ	N. A.	N. A.	Patented	[3]
US8846654, 251	DMML258	N. A.	N. A.	Patented	[3]
US8846654, 294	DMP3RCH	N. A.	N. A.	Patented	[3]
US9493447, 1001	DM4MJ3U	N. A.	N. A.	Patented	[4]
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⏷ Show the Full List of 6 Patented Agent(s)

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-04957325	DMPEZKT	Inflammation	1A00-CA43.1	Investigative	[5]
PF-4957325-00	DMV4P7S	Inflammation	1A00-CA43.1	Investigative	[1]
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References

1	PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One. 2010 Aug 9;5(8):e12011.
2	Inhibitors of phosphodiesterase 11 (PDE11). US9173884.
3	Therapeutic applications in the cardiovascular field of quinazolinedione derivatives. US8846654.
4	Optically active PDE10 inhibitor. US9493447.
5	Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.Front Pharmacol. 2016 Aug 23;7:259.