Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIX0ZU)

• DTT Name: MEKK2 messenger RNA (MAP3K2 mRNA)
• Synonyms: Mitogen-activated protein kinase kinase kinase 2 (mRNA); MEKK2 (mRNA); MEKK 2 (mRNA); MEK kinase 2 (mRNA); MAPKKK2 (mRNA)
• Gene Name: MAP3K2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: M3K2_HUMAN
• TTD ID: T52501
• EC Number: EC 2.7.11.25
• Sequence:
  MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
  RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV
  INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN
  GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY
  PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS
  FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK
  LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ
  YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV
  HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR
  KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE
  AKLRPSADELLRHMFVHYH
• Function: Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics. Component of a protein kinase signal transduction cascade.
• KEGG Pathway:
  MAPK signaling pathway (hsa04010)
  Gap junction (hsa04540)
  GnRH signaling pathway (hsa04912)

Molecular Interaction Atlas (MIA) of This DTT

13 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 113858	DM9D3F1	Discovery agent	N.A.	Investigative	[1]
ISIS 113871	DMTEUDL	Discovery agent	N.A.	Investigative	[1]
ISIS 113872	DMR05YO	Discovery agent	N.A.	Investigative	[1]
ISIS 113873	DMHUC3Q	Discovery agent	N.A.	Investigative	[1]
ISIS 113874	DMEMSW1	Discovery agent	N.A.	Investigative	[1]
ISIS 113902	DMI8NYF	Discovery agent	N.A.	Investigative	[1]
ISIS 113903	DM56A89	Discovery agent	N.A.	Investigative	[1]
ISIS 113904	DMBM7HD	Discovery agent	N.A.	Investigative	[1]
ISIS 113905	DMPRDXO	Discovery agent	N.A.	Investigative	[1]
ISIS 113906	DMPJAB5	Discovery agent	N.A.	Investigative	[1]
ISIS 113907	DMP6WE0	Discovery agent	N.A.	Investigative	[1]
ISIS 113908	DMKLZ2H	Discovery agent	N.A.	Investigative	[1]
ISIS 113909	DM0B9V5	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 6,287,860, Antisense inhibition of MEKK2 expression.