General Information of Drug Therapeutic Target (DTT) (ID: TTIXUDE)

DTT Name S100 calcium-binding protein G (S100G)
Synonyms Vitamin D-dependent calcium-binding protein, intestinal; S100D; Protein S100-G; Calbindin-D9k; CALB3; CABP9K; CABP
Gene Name S100G
DTT Type
Literature-reported target
[1]
BioChemical Class
S100 calcium-binding protein
UniProt ID
S100G_HUMAN
TTD ID
T06819
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSTKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEFPSLLKGPNTLDDLFQELDKN
GDGEVSFEEFQVLVKKISQ
Function
Vitamin D-dependent. Its expression correlates with calcium transport activity. May increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles.
KEGG Pathway
Mineral absorption (hsa04978 )

References

1 A model for target protein binding to calcium-activated S100 dimers. FEBS Lett. 1998 Jan 16;421(3):175-9.