Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJ2TSA)

DTT Name	Prolactin (PRL)
Synonyms	GHA1
Gene Name	PRL
DTT Type	Discontinued target	[1]
BioChemical Class	Somatotropin/prolactin
UniProt ID	PRL_HUMAN
TTD ID	T32282
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
Function	Prolactin acts primarily on the mammary gland by promoting lactation.
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 ) Neuroactive ligand-receptor interaction (hsa04080 ) PI3K-Akt signaling pathway (hsa04151 ) Jak-STAT signaling pathway (hsa04630 ) Prolactin signaling pathway (hsa04917 )
Reactome Pathway	Amyloid formation (R-HSA-977225 ) Growth hormone receptor signaling (R-HSA-982772 ) Prolactin receptor signaling (R-HSA-1170546 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NTx-488	DMX9KYW	Multiple sclerosis	8A40	Discontinued in Phase 2	[1]
------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028330)