Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJ4EIV)

• DTT Name: MERS-CoV spike glycoprotein S2 subunit (S S2)
• Synonyms: MERS-CoV S glycoprotein S2 subunit; MERS-CoV E2 S2 subunit; MERS-CoV Peplomer protein S2 subunit
• Gene Name: MERS-CoV S
• BioChemical Class: Betacoronaviruses spike protein family
• UniProt ID: A0A140AYZ5_9BETC (748-1353)
• TTD ID: T90035
• Sequence:
  TPSTLTPRSVRSVPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQEYIQTTIQ
  KVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSP
  IIPGFGGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASA
  RDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRL
  NGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFRKVQDAVNNNAQALSKLASEL
  SNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAK
  DKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAAN
  PTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKYVAPQVTYQNISTNLPP
  PLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTYEMLSLQQVVKALNESY
  IDLKELGNYTYYNKWPWYIWLGFIAGLVALALCVFFILCCTGCGTNCMGKLKCNRCCDRY
  EEYDLEPHKVHVH
• Function: Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

Molecular Interaction Atlas (MIA) of This DTT

4 Preclinical Drugs Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HR1P peptide	DMNF9P5	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
HR2P peptide	DM6WC1Q	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
HR2P-M1 peptide	DMSR96X	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
HR2P-M2 peptide	DM7X4SV	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]

References

• [1] Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014;5:3067.