Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJ8EWH)

DTT Name	Arginine vasopressin (AVP)
Synonyms	Vasopressin-neurophysin 2-copeptin; VP; Copeptin; AVP-NPII; ARVP
Gene Name	AVP
DTT Type	Literature-reported target	[1]
UniProt ID	NEU2_HUMAN
TTD ID	T20975
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCA DELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGF HRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY
Function	Neurophysin 2 specifically binds vasopressin.
KEGG Pathway	Vasopressin-regulated water reabsorption (hsa04962 )
Reactome Pathway	Vasopressin-like receptors (R-HSA-388479 ) G alpha (q) signalling events (R-HSA-416476 ) G alpha (s) signalling events (R-HSA-418555 ) Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040 ) BMAL1 (R-HSA-1368108 )

References

1	Emergent early markers of renal progression in autosomal-dominant polycystic kidney disease patients: implications for prevention and treatment. Am J Nephrol. 2012;36(2):162-7.