Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJC376)

• DTT Name: Carbonic anhydrase VII (CA-VII)
• Synonyms: Carbonic anhydrase 7; Carbonate dehydratase VII
• Gene Name: CA7
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Alpha-carbonic anhydrase
• UniProt ID: CAH7_HUMAN
• TTD ID: T37541
• EC Number: EC 4.2.1.1
• Sequence:
  MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
  ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
  HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
  FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
  IHMVNNFRPPQPLKGRVVKASFRA
• Function: Reversible hydration of carbon dioxide.
• KEGG Pathway:
  Nitrogen metabolism (hsa00910)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Reversible hydration of carbon dioxide (R-HSA-1475029)

References

• [1] Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740.