Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJOCE4)

DTT Name	Deoxycytidine kinase (DCK)
Synonyms	dCK
Gene Name	DCK
DTT Type	Literature-reported target	[1]
BioChemical Class	Kinase
UniProt ID	DCK_HUMAN
TTD ID	T98089
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.7.1.74
Sequence	MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE DFKDKYESLVEKVKEFLSTL
Function	Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
KEGG Pathway	Purine metabolism (hsa00230 ) Pyrimidine metabolism (hsa00240 ) Metabolic pathways (hsa01100 ) Nucleotide metabolism (hsa01232 )
Reactome Pathway	Purine salvage (R-HSA-74217 ) Pyrimidine salvage (R-HSA-73614 )
BioCyc Pathway	MetaCyc:HS08100-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LP-661438	DMGMO3Q	Discovery agent	N.A.	Investigative	[1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Deoxycytidine kinase (DCK) DME Info

Gene Name

DCK

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[2]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[3]
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References

1	236th ACS National Meeting
2	Potential mechanisms of action related to the efficacy and safety of cladribine. Mult Scler Relat Disord. 2019 May;30:176-186.
3	FDA label of Belinostat. The 2020 official website of the U.S. Food and Drug Administration.