Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJOMH6)

• DTT Name: Zinc finger protein GLI1 (Gli1)
• Synonyms: Oncogene GLI; Glioma-associated oncogene; GLI
• Gene Name: GLI1
• DTT Type: Patented-recorded target; [1]
• UniProt ID: GLI1_HUMAN
• TTD ID: T40890
• Sequence:
  MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
  SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
  YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
  SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
  GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
  HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
  PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
  GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
  LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
  RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
  TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
  GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
  YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
  GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
  PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
  YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
  SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
  GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
  PNMAVGNMSVLLRSLPGETEFLNSSA
• Function: Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Acts as a transcriptional activator.
• KEGG Pathway:
  cAMP signaling pathway (hsa04024)
  Hedgehog signaling pathway (hsa04340)
  Pathways in cancer (hsa05200)
  Basal cell carcinoma (hsa05217)
• Reactome Pathway:
  Hedgehog 'off' state (R-HSA-5610787)
  Hedgehog 'on' state (R-HSA-5632684)
  GLI proteins bind promoters of Hh responsive genes to promote transcription (R-HSA-5635851)
  Degradation of GLI1 by the proteasome (R-HSA-5610780)

Molecular Interaction Atlas (MIA) of This DTT

12 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imidazo bicyclic iminium derivative 1	DM01RXU	N. A.	N. A.	Patented	[1]
Imidazo bicyclic iminium derivative 2	DMA7DI6	N. A.	N. A.	Patented	[1]
Isoflavone derivative 1	DMMCWH9	N. A.	N. A.	Patented	[1]
Isoflavone derivative 2	DMTWAH3	N. A.	N. A.	Patented	[1]
Isoflavone derivative 3	DMYFKR2	N. A.	N. A.	Patented	[1]
Isoflavone derivative 4	DMYRU7I	N. A.	N. A.	Patented	[1]
Isoflavone derivative 5	DM2GL47	N. A.	N. A.	Patented	[1]
Isoflavone derivative 6	DM2ZYVL	N. A.	N. A.	Patented	[1]
Isoflavone derivative 7	DMNCHBL	N. A.	N. A.	Patented	[1]
Isoflavone derivative 8	DMN0XJQ	N. A.	N. A.	Patented	[1]
Isoflavone derivative 9	DMA78MD	N. A.	N. A.	Patented	[1]
PMID26666870-Compound-16	DMMGQ7Z	N. A.	N. A.	Patented	[1]

References

• [1] Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35.