Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJOW1I)

DTT Name Mannoside acetylglucosaminyltransferase 2 (MGAT2)
Synonyms
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; Beta-1,2-N-acetylglucosaminyltransferase II; Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Gene Name MGAT2
DTT Type
Patented-recorded target
 [1]
BioChemical Class
Glycosyltransferases
UniProt ID
MGAT2_HUMAN
TTD ID
T67812
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.4.1.143
Sequence
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
Function
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Plays an essential role in protein N-glycosylation.
KEGG Pathway
N-Glycan biosynthesis (hsa00510 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Maturation of spike protein (R-HSA-9694548 )
Reactions specific to the complex N-glycan synthesis pathway (R-HSA-975578 )
Defective MGAT2 causes CDG-2a (R-HSA-4793952 )
BioCyc Pathway
MetaCyc:HS09725-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
6 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bicyclic pyrimidine derivative 1 DMAJ74C N. A. N. A. Patented [1]
Dihydropyrimidinone derivative 3 DMA1S6Q N. A. N. A. Patented [1]
Dihydropyrimidinone derivative 4 DMNEKOZ N. A. N. A. Patented [1]
N-containing heterocyclic derivative 1 DM6TMXL N. A. N. A. Patented [1]
Phenylmethanesulfonamide derivative 1 DM1BIY4 N. A. N. A. Patented [1]
Pyrimidine-4(3H)-one derivative 1 DMT6O1N N. A. N. A. Patented [1]
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⏷ Show the Full List of 6 Patented Agent(s)

References

1 Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.