Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJTRMK)

DTT Name Interleukin 10 receptor (IL10RB)
Synonyms
Interleukin-10 receptor subunit beta; Interleukin-10 receptor subunit 2; IL-10RB; IL-10R2; IL-10R subunit beta; IL-10R subunit 2; IL-10 receptor subunit beta; D21S66; D21S58; Cytokine receptor family 2 member 4; Cytokine receptor class-II member 4; CRFB4; CRF2-4; CDw210b
Gene Name IL10RB
DTT Type
Literature-reported target
 [1]
BioChemical Class
Cytokine receptor
UniProt ID
I10R2_HUMAN
TTD ID
T14557
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYR
IFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQV
EVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRN
LEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLG
CFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAE
DSESGKQNPGDSCSLGTPPGQGPQS
Function
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
Jak-STAT signaling pathway (hsa04630 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Epstein-Barr virus infection (hsa05169 )
Reactome Pathway
Interleukin-10 signaling (R-HSA-6783783 )
Interleukin-20 family signaling (R-HSA-8854691 )
Other interleukin signaling (R-HSA-449836 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
EG-10 DMRP9K3 Inflammatory bowel disease DD72 Investigative [1]
VT-310 DM1QBXM Inflammation 1A00-CA43.1 Investigative [1]
XT-101 DM7BTNF Neuropathic pain 8E43.0 Investigative [1]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1900).