Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTJZNIG)

DTT Name MEKK3 messenger RNA (MAP3K3 mRNA)
Synonyms Mitogen-activated protein kinase kinase kinase 3 (mRNA); MEKK3 (mRNA); MEKK 3 (mRNA); MEK kinase 3 (mRNA); MAPKKK3 (mRNA)
Gene Name MAP3K3
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
M3K3_HUMAN
TTD ID
T11747
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.11.25
Sequence
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
RRIFVEARQRPSAEELLTHHFAQLMY
Function Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Component of a protein kinase signal transduction cascade.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
Neurotrophin signaling pathway (hsa04722 )
GnRH signaling pathway (hsa04912 )
HTLV-I infection (hsa05166 )
Reactome Pathway
Interleukin-1 signaling (R-HSA-446652 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
10 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 122970 DM0LMQH Discovery agent N.A. Investigative [1]
ISIS 122971 DM4NBX0 Discovery agent N.A. Investigative [1]
ISIS 122974 DMLHA6K Discovery agent N.A. Investigative [1]
ISIS 122975 DM4Y8EQ Discovery agent N.A. Investigative [1]
ISIS 122976 DM7OSZI Discovery agent N.A. Investigative [1]
ISIS 122984 DMVZS1D Discovery agent N.A. Investigative [1]
ISIS 122985 DM6JVOP Discovery agent N.A. Investigative [1]
ISIS 122986 DMU79FD Discovery agent N.A. Investigative [1]
ISIS 122990 DMLN8XS Discovery agent N.A. Investigative [1]
ISIS 122991 DMHAWMV Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 10 Investigative Drug(s)

References

1 US patent application no. 6,498,035, Antisense modulation of MEKK3 expression.