Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTK1V5Q)

• DTT Name: Nucleolin messenger RNA (NCL mRNA)
• Synonyms: Protein C23 (mRNA); Nucleolin (mRNA)
• Gene Name: NCL
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: NUCL_HUMAN
• TTD ID: T42004
• Sequence:
  MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATS
  AKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVA
  TPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAA
  APASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEE
  DDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEG
  TEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDL
  EKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIR
  LVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNST
  WSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEAL
  NSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARI
  VTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGR
  GGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
• Function: It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin is the major nucleolar protein of growing eukaryotic cells.
• KEGG Pathway: Pathogenic Escherichia coli infection (hsa05130)
• Reactome Pathway: Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Molecular Interaction Atlas (MIA) of This DTT

7 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 110064	DMXNG1S	Discovery agent	N.A.	Investigative	[1]
ISIS 110065	DMBOU16	Discovery agent	N.A.	Investigative	[1]
ISIS 110066	DM4B35Y	Discovery agent	N.A.	Investigative	[1]
ISIS 110067	DM0EFHM	Discovery agent	N.A.	Investigative	[1]
ISIS 110068	DMSLOKM	Discovery agent	N.A.	Investigative	[1]
ISIS 110073	DMUG4HJ	Discovery agent	N.A.	Investigative	[1]
ISIS 110074	DM2KECW	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 6,165,786, Antisense modulation of nucleolin expression.